Clinicopathological value of epidermal growth factor receptor (EGFR) and Ki-67 expression in colorectal adenoma and adenocarcinoma

Objective: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma carcinoma cases, to relate their with the available clinicopathological data.Methods: The retrospective study was conducted at Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 October 2020, comprised formalin-fixed paraffin-embedded specimens related cases those carcinoma, who had no previous radiation or chemotherapeutic treatment. Immunohistochemical staining all thecases done using anti-epidermal anti-Ki-67 antibodies. Data analysed SPSS 20.Results: Of 70 20(28.5%) were adenoma; mean age 52.95±13.47 years, male-to-female ratio 1:1. remaining 50(71.5%) carcinoma; 51.08±13.49 1.17:1. Epidermal overexpression significantly villous histopathological type high-grade dysplasia (p<0.05). In growthfactor tumour grade increased pathological stage (p<0.05).Conclusions: Overexpression found be an ominous sign aggressiveness, risk progression carcinoma.Keywords: Antigen, Adenoma, Colorectal neoplasms, Receptors, Carcinoma.